Working groups

For a better understanding of the disease a thorough phenotype genotype analysis is needed. This working group will harmonize SOP’s.

Working group 2 will provide a standardized means of performing quality control and analyses for project MinE.

The interest of this working group are epigenetic processes that regulate gene expression via modifications to DNA, histone proteins, and chromatin.

The aim of this working group is to discover large genetic changes, like repeat expansions, CNVs and SVs from WGS data that are eligible causes of ALS.

This working group aims to determine the non-coding genomic variation by focussing on burden analysis on coding genes and associated non-coding elements and specific classes on non-coding RNA’s, with the use of a machine learning approach.

The overall aim of this working group is to diversify genetic research in ALS to include diverse, multi-ethnic populations to accurately represent ALS genetics-related disease risks in all populations.