Universita degli Studi dei Torino
About the center
Project MinE Italy is run by our research partners at University of Turin and University of Milan Medical School at IRCCS Istituto Auxologico Italiano.
The ALS Centre in Milan, at the Department of Neurology-Stroke Unit of the University of Milan Medical School at the IRCCS Istituto Auxologico Italiano has large interests in many aspects of ALS, but specifically, in the past few years, in defining the genetics of both FALS and SALS. Prof. Silani contributed with his large team to the discovery of new genes in FALS (Profilin1, TUBA4A, TBK1, NEK1) and to the finalization of the two largest GWAS in SALS. Project MinE is considered an obligatory step in further defining the genetic basis of ALS, after completing the exome sequence of several hundred ALS patients. Envisioning a future where the therapy for ALS patients is based on a precision medicine approach, stratification of patients according to their genetic risk factors appears an obligatory step to design molecularly tailored interventions.
