Trinity College Dublin
About the center
The Academic Unit of Neurology of Trinity College Dublin, Research Motor Neurone (RMN) and the Irish Motor Neurone Disease Association (iMNDA) are partners in Project MinE and aim to analyse 700 DNA samples of ALS patients and 350 DNA samples of control subjects.
The Academic Unit of Neurology is part of the School of Medicine at Trinity College Dublin and houses the Irish ALS Research Group. The Unit has close links with colleagues at the Institute of Neuroscience, and the Neurology Units at St. James and Tallaght Hospital and the National Neuroscience Centre at Beaumont Hospital. The Irish ALS Research Group includes international experts in cognition, imaging, clinical management, epidemiology and genetics of ALS. Our group has conducted the first population based longitudinal study of cognition and behaviour in ALS, was the first to show that the phenotype and natural history of incident and prevalent patients with ALS/MND differs; that attendance at a multidisciplinary clinic independently improves survival, and that the presence of executive impairment is an important determinant of disease progression.
Project MinE is important to our group as we have already shown that the gene ANG as an important genetic modifier in ALS, that genetic admixture is likely to be protective in ALS, and that some neuropsychiatric conditions occur with higher frequency in ALS kindred, suggesting a commonality in genetic susceptibility. As the Irish population is genetically homogeneous and the Irish Register collects detailed clinical information about the condition, our ongoing work in the genetics of ALS in the Irish population is likely to provide further important insights into ALS that can in turn translate into earlier diagnoses and new treatments.
