Publication overview

Research center

CHU de Québec-Université Laval

Quebec, Canada

CHU de Québec-Université Laval

About the center

“Why have I been diagnosed with ALS when so many other people have not?” This is an all-too-common question of people living with the devastation of an ALS diagnosis, and the ALS Society of Canada (ALS Canada) wants to help answer it. We are leading Canada’s fundraising efforts for Project MinE to support the sequencing of up to 1,000 Canadian genomes.

As a national organization responsible for the ALS Canada Research Program, we aim to accelerate research impact through a comprehensive national program focused on translating scientific discoveries into treatments for ALS and fostering Canada’s strong and networked ALS research community to build capacity and collaboration. Support for the ALS Canada Research Program is made possible by the generosity of donors, ALS Societies across Canada, Brain Canada and the federal government’s Canada Brain Research Fund.

The Canadian component of Project MinE brings together four of Canada’s leading ALS geneticists in Vancouver, Toronto, Montreal and Quebec City for their first ever cross-country collaboration. Each has led or been part of international consortia that have resulted in some of the most important genetic discoveries in the field. They also represent a geographical balance that provides a collaborative set of Canadian samples representative of ALS cases across the country.

Other essential collaborators in Canada’s Project MinE effort are the four Canadian ALS clinics that are collecting and in some cases storing the blood samples being used for the initiative: the GF Strong Rehabilitation Centre’s ALS Centre in Vancouver, the Sunnybrook Health Sciences Centre ALS Clinic in Toronto, the ALS Program at the Montreal Neurological Institute and Hospital, and the ALS Clinic at the CHU de Québec.

Nicolas Dupré

Neurologist; Assistant Professor, Faculty of Medicine, Université Laval; Clinician-Scientist, Axe Neurosciences

CHU de Québec-Université Laval

Nicolas Dupré

Neurologist; Assistant Professor, Faculty of Medicine, Université Laval; Clinician-Scientist, Axe Neurosciences

Dr. Dupré has made major contributions both locally and internationally to the fields of neuromuscular and neurogenetic medicine, and has published more than 100 peer-reviewed papers and five book chapters.

He is currently the director of the Neuromuscular & Neurogenetic Disease Clinic of the CHU de Québec – U Laval, taking care of thousands of patients from the Eastern Quebec area afflicted with rare and common diseases of the nervous system.

Dr. Dupré was involved in the 2008 discovery that the gene TDP-43 is involved in ALS. He also helped to establish the ALS clinic at the CHU de Québec, providing care to patients in Eastern Quebec.