Publications - Project MinE

Research

Publications

Project MinE* is a patient-driven groundbreaking genetic ALS research. The project is a worldwide collaboration between ALS centres and foundations.

All Project MinE data used in the listed publications were made accessible and available through funding by the Dutch ALS Foundation and co-funding by the PPP Allowance made available by Health~Holland, Top Sector Life Sciences & Health, to stimulate public-private partnerships.

Project MinE: study design and pilot analyses of a large-scale whole-genome sequencing study in amyotrophic lateral sclerosis

W. van Rheenen et al., European Journal of Human Genetics, 2018

The most recent genome-wide association study in amyotrophic lateral sclerosis (ALS) demonstrates a disproportionate contribution from low-frequency variants to genetic […]

NEK1 variants confer susceptibility to amyotrophic lateral sclerosis

K. Kenna et al., Nature Genetics, 2016

To identify genetic factors contributing to amyotrophic lateral sclerosis (ALS), we conducted whole-exome analyses of 1,022 index familial ALS (FALS) […]

Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis

W. van Rheenen et al., Nature Genetics, 2016

To elucidate the genetic architecture of amyotrophic lateral sclerosis (ALS) and find associated loci, we assembled a custom imputation reference […]